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Crash 3 Trial Pdf Download

 
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MessagePosté le: Jeu 1 Sep - 11:58 (2016)    Sujet du message: Crash 3 Trial Pdf Download Répondre en citant




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Crash 3 Trial Pdf Download

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Anti-fibrinolytic,,use,,for,,minimising,,perioperative,,allogeneic,,blood,,transfusion.,,The,,depth,,(C),,was,,determined,,by,,multiplying,,the,,number,,of,,slices,,on,,which,,haematoma,,is,,visible,,by,,the,,slice,,interval,,thickness,,listed,,on,,the,,CT,,scan.,,The,,,mean,,,total,,,haemorrhage,,,growth,,,was,,,5.9,,,ml,,,(SD,,,26.8),,,and,,,8.1,,,mL,,,(SD,,,29.2),,,in,,,the,,,tranexamic,,,acid,,,and,,,placebo,,,groups,,,respectively,,,(adjusted,,,difference,,,3.8,,,mL,,,(95%,,,confidence,,,interval,,,11.5,,,to,,,3.9)).,,,Your,browser,doesn't,accept,cookies.,In:,,,Warrell,,,DA,,,,Cox,,,TM,,,,Firth,,,JD,,,,eds.,,,Nevertheless,,the,relatively,small,sample,size,does,not,affect,the,internal,validity,of,this,study,,and,,although,imprecise,,the,results,should,be,unbiased.Implications,of,resultsThe,CRASH-2,trial,has,shown,reliably,that,early,administration,of,tranexamic,acid,in,trauma,patients,with,,or,at,risk,of,,significant,bleeding,reduces,the,risk,of,all,cause,mortality.,Our,,,findings,,,differ,,,from,,,those,,,reported,,,in,,,a,,,systematic,,,review,,,of,,,randomised,,,controlled,,,trials,,,of,,,tranexamic,,,acid,,,in,,,patients,,,with,,,aneurysmal,,,subarachnoid,,,haemorrhage,,,,which,,,found,,,that,,,tranexamic,,,acid,,,reduced,,,the,,,rate,,,of,,,re-bleeding,,,but,,,increased,,,cerebral,,,ischaemia.20,,,However,,,,the,,,doses,,,of,,,tranexamic,,,acid,,,used,,,in,,,these,,,trials,,,were,,,larger,,,and,,,more,,,prolonged,,,than,,,in,,,our,,,study.,,,In,,,theory,,,,if,,,tranexamic,,,acid,,,reduces,,,intracranial,,,haemorrhage,,,after,,,traumatic,,,brain,,,injury,,,without,,,increasing,,,the,,,risk,,,of,,,ischaemic,,,lesions,,,,it,,,could,,,substantially,,,improve,,,patient,,,outcomes.,,,

J,Neurotrauma2008;25:629-39.OpenUrlCrossRefMedlineWeb,of,SciencePerel,P,,Roberts,I,,Bouamra,O,,Woodford,M,,Mooney,J,,Lecky,F.,Royal,London,Hospital,and,Lahore,General,Hospital,(LGH),Unit,II,have,between,them,,recruited,over,500,patients,to,the,trial.,We,,reported,,95%,,confidence,,intervals,,for,,all,,the,,effects,,estimated,,and,,P,,values,,for,,the,,adjusted,,analyses.Haemorrhage,,growth,,was,,analysed,,using,,multiple,,linear,,regression,,(analysis,,of,,covariance),,,the,,main,,factor,,being,,the,,treatment,,group.,,5th,ed.,Furthermore,,,,the,,,risk,,,and,,,mechanism,,,of,,,cerebral,,,ischaemia,,,is,,,different,,,in,,,the,,,two,,,conditions.Regarding,,,the,,,clinical,,,outcomes,,,,although,,,the,,,results,,,were,,,not,,,statistically,,,significant,,,,we,,,found,,,a,,,trend,,,towards,,,a,,,reduction,,,in,,,mortality,,,,without,,,any,,,evidence,,,of,,,increase,,,in,,,dependency,,,among,,,survivors.When,,,we,,,assessed,,,the,,,effect,,,of,,,tranexamic,,,acid,,,on,,,a,,,composite,,,outcome,,,that,,,considered,,,poor,,,computed,,,tomography,,,and,,,clinical,,,outcomes,,,we,,,found,,,a,,,statistically,,,significant,,,reduction.,,,The,,,maximum,,,linear,,,length,,,(A),,,in,,,cm,,,was,,,multiplied,,,by,,,the,,,maximum,,,width,,,perpendicular,,,to,,,A,,,(B),,,and,,,the,,,maximum,,,depth,,,(C),,,in,,,cm.,,,However,,,the,,analysis,,provides,,grounds,,for,,further,,clinical,,trials,,evaluating,,the,,effect,,of,,tranexamic,,acid,,in,,this,,population.Trial,,registration,,ISRCTN86750102.IntroductionThe,,antifibrinolytic,,tranexamic,,acid,,has,,been,,shown,,to,,reduce,,blood,,loss,,in,,surgical,,patients,,and,,the,,risk,,of,,death,,in,,patients,,with,,traumatic,,bleeding,,,with,,no,,apparent,,increase,,in,,vascular,,occlusive,,events.1,,2,,These,,findings,,raise,,the,,possibility,,that,,it,,might,,be,,effective,,in,,other,,situations,,in,,which,,bleeding,,can,,be,,life,,threatening,,or,,disabling.Traumatic,,brain,,injury,,is,,a,,leading,,cause,,of,,death,,and,,disability,,worldwide.,,New,focal,cerebral,ischaemic,lesions,occurred,in,6,(5%),patients,in,the,tranexamic,acid,group,versus,12,(9%),in,the,placebo,group,(adjusted,odds,ratio,0.51,(95%,confidence,interval,0.18,to,1.44)).,Main,,outcome,,measures,,Intracranial,,haemorrhage,,growth,,(measured,,by,,computed,,tomography),,between,,hospital,,admission,,and,,then,,2448,,hours,,later,,,with,,adjustment,,for,,Glasgow,,coma,,score,,,age,,,time,,from,,injury,,to,,the,,scans,,,and,,initial,,haemorrhage,,volume.,,The,,linear,,distance,,in,,cm,,between,,each,,corner,,of,,the,,epidural,,lens,,shape,,was,,used,,to,,determine,,the,,length,,(A).,,

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